Health Benefits at a Glance:
As you age, your skin naturally becomes less firm and loses its youthful look and feel. Advanced Growth Factor Serum uses a powerful combination of four different anti-aging Growth Factors that can contribute to maintaining better skin health.
Why it Works:
Youthful skin reflects the inner workings of anti-aging growth factors that drive tissue function and regeneration of e.g. collagen and skin hydration levels in response to both internal and external factors . As we grow older, a decrease in the concentrations of these four key Growth Factors inhibits the skin matrix and leads to the tell-tale signs of normal aging which are visible on your skin [1,2]. Replenishing these four Growth Factors supports your skin’s anti-aging process .
Advanced Growth Factor Serum can contribute to better skin health by using these four different Growth Factors. Each one can contribute to your skin health in a unique way.
Growth Factor 1: Epidermal Growth Factor - supports skin cell health. It can also contribute to the activation of a biological process that restores skin hydration .
Growth Factor 2: Insulin-like Growth Factor - supports the synthesis of collagen, elastin, and hyaluronic acid used for restoring skin hydration .
Growth Factor 3: Vascular Endothelial Growth Factor - supports the formation of new blood vessels. It also boosts the delivery of oxygen and nutrients to the extracellular environment .
Growth Factor 4: Fibroblast Growth Factor - supports the production of collagen and elastin, which gives your skin its elasticity and strength and a youthful look .
The Science Behind the Product:
Even though the skin produces different growth factors, only a very small minority of them actually play a crucial role in the healing process. The problem is that as we age, production of growth factors naturally declines and so does the skin supporting effect. Scientists have, however, pinpointed the following four growth factors involved in skin reparative processes:
- Epidermal growth factor (EGF)helps the proliferation of epithelial cells to enhance wound healing and activates hyaluronan synthase 2 which supports rehydration of the skin [3,7]
- Insulin-like growth factor-1 (IGF-1) stimulates the proliferation of fibroblasts which synthesizes skin matrix components, including collagen and elastin [4,8].
- Vascular endothelial growth factor (VEGF) stimulates the formation and growth of new blood vessels (angiogenesis). It can also increase vascular permeability to allow a greater delivery of oxygen and nutrients into the extracellular matrix that facilitates repair [5,9]
- Fibroblast growth factor (FGF) is an important player when it comes to proliferating and regenerating skin cells 
At the core of the matter, these growth factors work in harmony to support nourishment and restoration of the functionality and appearance of the extracellular matrix. This can help retain healthy, youthful skin. As the oxidative damage accumulates with age, it speeds up the loss of collagen, elastin, and hyaluronic acid which is associated with skin cell aging. That can result in dry skin, fine lines, and wrinkles.
In a clinical trial study which was performed on twelve women, ages 43-50, participants applied a topical cream of these growth factors, glutamine, and folic acid on a daily basis to their facial region for four full weeks. The researchers were able to show that when topically applied as a cream, these four growth factors produce noticeable effects that result in firmer, younger-looking skin.
How to Use:
- Apply twice daily to clean dry skin, morning and night.
- Place two pumps into palm of hand.
- Apply to the face and neck in an upward motion.
Read original source
- Martin P. Science. 1997 Apr;276(5309):75-81.
- Fabi S. Facial Plast Surg. 2014;30:157-171.
- Pienimaki JP et al. J Biol Chem. 2001 Jun;276(23):20428-35.
- Gartner MH et al. J Surg Res. 1992 Apr;52(4):389-94.
- Ferrara N. Am J Physiol Cell Physiol. 2001 Jun;280(6):C1358-66.
- Takehara K. J Dermatol Sci. 2000 Dec;24 Suppl 1:S70-7.
- Hardwicke J, Schmaljohann D, Boyce D, et al. Epidermal growth factor therapy and wound healing--past, present and future perspectives. Surgeon. 2008;6(3):172-7.
- Svegliati-Baroni G, Ridolfi F, Di Sario A, et al. Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways. Hepatology. 1999;29(6):1743-51.
- Tran KT, Griffith L, Wells A. Extracellular matrix signaling through growth factor receptors during wound healing. Wound Repair Regen. 2004;12(3):262-8.
- An JJ, Eum WS, Kwon HS, et al. Protective effects of skin permeable epidermal and fibroblast growth factor against ultraviolet-induced skin damage and human skin wrinkles. J Cosmet Dermatol. 2013;12(4):287-95.