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Brain-Restoring Impact of Magnesium L-Threonate

Brain-Restoring Impact of Magnesium L-Threonate
By Frederik 2 years ago 5533 Views

By Susan Goldschein

MIT researchers discovered and patented magnesium L-threonate based on its unique ability to boost brain levels of magnesium. Rapid absorption and ability to enter the brain enables this magnesium to structurally reverse certain aspects of brain aging [1-4]. A recent human study demonstrates the benefits of magnesium L-threonate in adults with cognitive dysfunction, sleep disorders, and anxiety [1].

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MgT has unique abilities

The most startling finding is a reversal of more than nine years in clinical measures of brain aging in people who supplemented with magnesium L-threonate. Magnesium L-threonate (MgT) was developed at the Massachusetts Institute of Technology [2].

MgT (pronounced “Mag T”) is special because of the way it boosts brain magnesium levels when taken orally. This effect is due to its unique ability to cross the blood-brain barrier [2]. Research has shown that once MgT gets into the brain, it increases the density of synapses, which are the communication connections between brain cells [1].

This is critical because loss of synaptic density is associated with brain shrinkage and cognitive decline [5,6].


  1. Liu G, Weinger JG, Lu ZL, et al. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2016;49(4):971-90.
  2. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165-77.
  3. Abumaria N, Yin B, Zhang L, et al. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. J Neurosci. 2011;31(42):14871-81.
  4. Li W, Yu J, Liu Y, et al. Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model. Mol Brain. 2014;7:65.
  5. Fox NC, Scahill RI, Crum WR, et al. Correlation between rates of brain atrophy and cognitive decline in AD. Neurology. 1999;52(8):1687-9.
  6. Terry RD, Masliah E, Salmon DP, et al. Physical basis of cognitive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991;30(4):572-80.