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Dr. Sandra Kaufmann: The Science of Slowing Aging

Dr. Sandra Kaufmann: The Science of Slowing Aging
By Frederik 1 years ago 2616 Views

September 2018

By Gary Greenberg


150x180px Dr. Sandra Kaufmann, M.D.

Sandra Kaufmann, M.D., is Chief of Pediatric Anesthesiology at Joe DiMaggio Children’s Hospital in Hollywood, Fla.

The 49-year-old married mother of two is also an athlete who enjoys running, swimming, and rock climbing. When she hit her mid-40s, Kaufmann decided she didn’t want to succumb to the ravages of time and began exploring ways to fight back against what has always been the inevitable decline of aging.

Armed with years of higher education that not only included her medical degrees but also a masters in ecology and evolutionary biology with an emphasis on cellular plasticity under changing environmental conditions, she scrutinized thousands of scientific studies on hundreds of potentially anti-aging substances.

The results are detailed in her new book, The Kaufmann Protocol: Why We Age and How to Stop It, available in e-book form from Amazon.com. In it, she describes the mechanisms of aging on a cellular level and the best substances to retard its progress.


Life Extension® caught up with Dr. Kaufmann a few days before she headed off on an expedition to the base camp of Mount Everest.


LE: It seems ironic that a children’s doctor should become an expert in aging.


SK: I appreciate the irony but, on the other hand, spending so much time with kids serves to remind me that the clock is always ticking.


LE: How is your book different from the many other anti-aging books and programs on the market?


SK: My book is not about diet and exercise, and has little mention of carbohydrates or ketones. It doesn’t include anything about colonic cleansing or any other fad or exotic treatment to prevent aging.

My book is based solely on how to maintain cellular health. We are made of cells, and we age because our cells age.

You have to change your perspective from organs to cells, from “what does my skin look like?” to “what are my skin cells doing?” You have to look inside the cells, which is what I have done.




(5 Tips to Look Great in 10 Years – video in English only)


LE: What are the mechanics of aging?


SK: Aging consists of seven categories of things that happen to your cells.

No. 1: Changes to DNA, including epigenetic modification and telomere length.

No. 2: Disruptions in energy production due to mitochondria failure.

No. 3: Problems with metabolic pathways, especially the sirtuins, AMPK, and mTOR pathways.

No 4: Quality control problems that affect DNA and protein repair.

No. 5: Inflammatory issues due to a faulty immune system.

No. 6: Not fulfilling the needs of specific cells.

No. 7: Incomplete waste management.


To defeat aging, or decelerate the process, you have to take into consideration each of the seven categories.

LE: Are any of those seven categories more important than others?


SK: They are all interrelated and dependent on each other. The ratio of what’s important may change over time. For example, when you are young, you have less DNA damage, so the DNA repair mechanisms are less active. As you get older, you have more DNA damage and less capacity to fix it, so that category becomes extraordinarily important. I separated the categories to explain the process. But in practice they are so interrelated it’s virtually impossible to separate them…


You can read the rest of the article here (English only).


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