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Probiotics Rebalance a Dysbiotic Microbiome

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Probiotics Rebalance a Dysbiotic Microbiome
By Frederik 2 years ago 3820 Views

What can we do to restore the all-important balance to dysbiotic microbiomes?

By Stanley Remmick

The discovery of the human microbiome is changing the ways we think about health and disease.

Microbiome is the term for the trillions of living organisms that reside in and on the human body. An estimated 100 trillion microorganisms live in the gut alone—that’s up to ten times the number of cells that make up the body itself.1

More than 70% of the human immune system is found in the lining of the gut.2 Based on this information, researchers have now found a new kind of health-promoting therapy: targeted cultures of beneficial bacteria (probiotics) that are fine-tuned to modify imbalanced microbiomes back into a healthy equilibrium.

What can we do to restore the all-important balance to dysbiotic microbiomes?

Killing bacteria with antibiotics is like using a sledgehammer to kill a fly—it’s much more destructive than effective, killing off dozens or hundreds of healthy bacteria to cope with a few unhealthy bacteria.

Fortunately, we have a growing array of weapons in our arsenal to fight dysbiosis and restore healthy, balanced microbiomes, in the form of beneficial bacteria generally known as probiotics.

Probiotic bacteria are derived from populations of known beneficial microorganisms, which produce specific compounds that contribute to human health, or help to suppress the less-beneficial microorganisms. Let’s look at each of these areas briefly, to understand the promise of the targeted probiotic revolution.

Multiple Bacterial Strains for Gut Microbiome Balance

Targeted probiotics have also been shown to improve healthy gene expression in intestinal immune cells—that gigantic community of human immune tissue that makes up more than 70% of our total immune function.4 Studies show that restoring the gut content of “friendly” bacteria can support healthy immune function.5

Probiotics Support Heart Health

A highly specific probiotic (Lactobacillus reuteri 30242) has now been developed, comprised of a single beneficial strain of Lactobacillus. This unique microorganism has been shown in clinical trials to safely support healthy cholesterol in adults who are already within the normal range.6-8 Furthermore, it has the ability to support healthy levels of a cholesterol carrier protein influences how and where cholesterol is delivered to body tissues.7

Mood Improvements with Probiotic Combination

Gut microbes help process a wide range of signaling molecules, including many essential hormones and neurotransmitters that brain cells use to communicate and send impulses.10 And inflammatory changes, driven in part by gut dysbiosis, can contribute to mood disorders. 3,11,12

Probiotic Formulation Boosts Immune Function

The human intestinal tract is where our immune systems meet our gut microbiome. It is now becoming clear that the gut microbiome plays an outsized role in “teaching” the immune system to distinguish between our own cells and other threatening cells and molecules. When the gut microbiome and immune system work together, we develop appropriate immune tolerance, so that our bodies learn to attack only real offenders and avoid destructive impact on our own tissues.

Throat Protection with Specialized Probiotic

The throat and oral microbiomes are also important in protecting our health. Makeup of the throat (pharyngeal) microbiome may be particularly important in preventing wintertime sore throats, including strep and viral infections.

Oral Health Promotion with Paired Probiotic Lozenge

A tremendous proportion of adults suffer from oral health disorders, particularly cavities and the gum disease gingivitis (which may progress to periodontitis, resulting in tooth loss).

Daily supplementation with this proven probiotic combination is an excellent way to augment regular brushing and flossing.

Allergy Relief

Even seasonal allergic symptoms can be driven—and remedied—by microbiome modulation involving the immune system. Now, thanks to advanced scientific breakthroughs, two ingredients have been identified that act at the top of that signaling cascade, effectively retraining the immune system to take pollen and other allergens in its stride and muting the excessive inflammatory responses that otherwise produce irritating allergy symptoms.

Summary

We’re experiencing the beginning of a true medical revolution with the discovery of the trillions of bacteria that make up our microbiome. These bacteria provide countless opportunities to improve and protect our health through careful balancing of the community composition.

Restoring balance has been repeatedly shown to reverse the consequences of dysbiosis, to protect us from disease, and to enhance our health and the prospects for longevity.

Studies now show that probiotic supplementation can rebalance dysbiotic microbiomes and protect us from disorders of the gut, brain, heart, and immune system. Similarly, probiotics targeting the oral and throat microbiomes can protect us against dental disease, gingivitis, and throat infections.

These potent formulations are only the beginning of a new era in medicine, when we learn to engage in partnerships with the other living beings that share our bodies and encourage them to ease us into better biological balance for longer, healthier lives.

We have a wide range of both probiotics and prebiotics. You can learn more about them here!

References

  1. Khanna, S, Tosh PK. A clinician’s primer on the role of the microbiome in human health and disease. Mayo Clin Proc. 2014;89(1):107-14.
  2. Vighi G, Marcucci F, Sensi L, et al. Allergy and the gastrointestinal system. Clin Exp Immunol.2008;153(Suppl 1):3-6.
  3. Jiang H, Ling Z, Zhang Y, et al. Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun.2015;48:186-94.
  4. Holmgren J, Czerkinsky C, Lycke N, et al. Mucosal immunity: implications for vaccine development. 1992;184(2-3):157-79.
  5. Calder PC, Kew S. The immune system: a target for functional foods? Br J Nutr.2002;88 Suppl 2:S165-77.
  6. Jones ML, Martoni CJ, Prakash S. Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial. Eur J Clin Nutr.2012;66(11):1234-41.
  7. Jones ML, Martoni CJ, Parent M, et al. Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults. Br J Nutr.2012;107(10):1505-13.
  8. Kumar M, Nagpal R, Kumar R, et al. Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. Exp Diabetes Res.2012;2012:902917.
  9. Jones ML, Martoni CJ, Prakash S. Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial. J Clin Endocrinol Metab.2013;98(7):2944-51.
  10. Usami M, Miyoshi M, Yamashita H. Gut microbiota and host metabolism in liver cirrhosis. World J Gastroenterol.2015;21(41):11597-608.
  11. Guida F, Turco F, Iannotta M, et al. Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice. Brain Behav Immun.
  12. Wong ML, Inserra A, Lewis MD, et al. Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition. Mol Psychiatry.2016;21(6):797-805.