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SAMe: The Mood Boosting Super Nutrient

SAMe: The Mood Boosting Super Nutrient
By Frederik 3 years ago 2726 Views


Marie Parks


Looking for optimal health support in one supplement? Adding the natural compound S-adenosylmethionine (known as SAMe) into your regimen may very well be your best move. Long prescribed in Europe to help treat depression, SAMe has been shown to be as effective as prescription drugs in improving mood and a range of other health conditions. SAMe is involved in many essential roles in your body such as detoxification, mood support, joint function, inflammation, and even DNA repair.


SAMe Is a Natural Mood Booster

While some people have severe mood disorders, most everyone experiences the blues from time to time. Being a methyl donor, SAMe plays a role in the methylation production of the neurotransmitters serotonin and dopamine.1 Serotonin and dopamine are the main “feel good” neurotransmitters which can improve mood and well-being!

People suffering from depression have lower levels of SAMe in their spinal fluid, and up to 46% percent of the people with depression have only a partial or no response to antidepressant medications.2, 3

One of the main obstacles preventing prescribed medications from being effective is their inability to cross the blood-brain barrier.4 Since SAMe can cross the blood-brain barrier, it can help increase levels in individuals, decreasing their depressive symptoms.

In a 2004 study, subjects who had incomplete responses or no responses to selective serotonin reuptake inhibitors (SSRIs) or Effexor® were given SAMe for six weeks. Of these subjects who were unresponsive or partially responsive to treatment, 50% experienced improvement with SAMe and 43% had remission of symptoms.


SAMe Offers Liver Protection

Your liver is involved in many crucial functions like storing nutrients and getting rid of toxins. So it comes as no surprise that the health of your liver affects the health of your whole body!

Glutathione is involved in phase 1 liver detoxification. Without glutathione, your liver is damaged after exposure to toxins like heavy metals and alcohol.6, 7 Since SAMe is a precursor to glutathione, it makes sense that it’s been shown to protect liver cells from oxidative stress and inflammation caused by toxins.

The pathway for producing SAMe is often blocked in cirrhosis patients, so SAMe may be essential in these patients for the proper functioning of their liver.9


SAMe Dosing

The dose depends on what you’re using it for and can range from 200 mg-1,600 mg per day. As usual, it’s suggested to start at a lower dose and work your way up.



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  2. J Neurol Neurosurg Psychiatry. 1990 Dec;53(12):1
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  4. Am J Med. 1987 Nov 20;83(5A):104-6.
  5. J Clin Psychopharmacol. 2004 Dec;24(6):661-4.
  6. Altern Med Rev. 2003 May;8(2):106-28.
  7. Gastroenterology.1998 Dec;115(6):1541-51.
  8. Alcohol. 2002 Jul;27(3):179-83.
  9. Drugs. 1990;40 Suppl 3:98-110.