One key molecule at the front and center of healthy aging is NAD+ (nicotinamide adenine dinucleotide). It is found in all our cells and is often called our body’s own master “longevity” molecule.
The impairment of senescent cells and tendency to promote inflammation contribute to loss of physical function and the risk for age-related disease and disability. Senolytic compounds have the ability to cleanse the body of these cells, improving organ function and preventing disease in animal models. Several compounds are being actively studied for these effects in humans and to define their optimal role in promoting longevity.
By Michael Downey