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Vitamin C Increases Longevity

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Vitamin C Increases Longevity
By Frederik 4 months ago 366 Views

March 2019

 

By Emily Watson

 

Humans do not internally produce vitamin C. Diets provide enough vitamin C to avoid scurvy, but nowhere near what may be optimal doses.

Researchers have found that vitamin C promotes a longer lifespan and can help prevent many of the disorders related to aging. In fact, vitamin C shows potential to significantly improve the quality of life.

 

Boosting Longevity

Animal studies show that vitamin C can reverse several age-related abnormalities in tissues. This includes reducing inflammatory responses, protecting DNA integrity, and reducing biomarkers of cellular stress. When left unaddressed, all of these are associated with rapid aging [2-5].

The evidence indicates that vitamin C is an important component to healthy longevity

 

WHAT YOU NEED TO KNOW

  • Vitamin C was one of the first vitamins to be discovered.
  • First noted for its ability to fight the connective tissue degeneration of scurvy, vitamin C has now been shown to have a vital relationship with biochemical reactions crucial to cellular health throughout the body.
  • Daily supplementation with vitamin C may help boost the immune system and protect the cardiovascular system.

 

https://www.youtube.com/watch?v=W_oDpGih3nM

 

Vitamin C Adds Cardio Protection

Lipid peroxidation, free radical damage to fats, is a crucial step in the development of atherosclerosis and heart disease. Studies show that vitamin C at doses of 1,000 mg per day lowers levels of oxidative-stress markers in blood, even during the high oxidative-stress period following a meal [5, 6].

Vitamin C has shown many beneficial effects in preventing cardiovascular disease:

Vitamin C preserved crucial cardiac stem cells, required for healing damaged heart tissue, in a lab study [7].

Two grams per day of vitamin C fully restored an important cardiovascular repair system in smokers after just 2 weeks of supplementation, giving them the same healing capacity as non-smokers [8].

A meta-analysis of 44 clinical trials showed that vitamin C supplementation improved endothelial function. The effect was stronger in those with higher cardiovascular risk [9].

 

Boost Immune Function, Cut Infection Risk

Vitamin C is especially beneficial to the immune system, helping to prevent viral respiratory infections like the common cold [10-11]. Immune system cells accumulate vitamin C, using it to create chemical “weapons” which destroy invading bacteria and viruses [12, 13].

Diminished levels of vitamin C leave us vulnerable to specific disease-causing microbes [11].

Vitamin C’s immune-boosting effects arise from multiple mechanisms: [11,12,14-17].

Promoting the actions of phagocytes, the cellular “eating machines” that chew up bacterial and fungal cells.

Activating T-cells, white blood cells, that scan the body for abnormalities and infections and direct both antibody-producing cells and killer cells to work against viruses and bacteria.

Mitigating oxidative stress and reducing unneeded inflammatory responses.

 

SUPPORTS HEALTHY COLLAGEN PRODUCTION

  • Collagen, a structural protein abundant in connective tissue and found throughout the body, makes up 30 % of all body protein. Collagen provides strength and durability to bone, skin, tendons, ligaments, blood vessels, and more [22].
  • The strength and resilience of much of our collagen decreases with age, contributing to age-related changes to skin, bone, and even our cardiovascular and respiratory systems [23, 24].

 

Bone Health

Large population studies have found that higher vitamin C intake is associated with greater bone mass, and that lower vitamin C intake correlates with bone loss [27]. And clinical studies have shown positive associations between vitamin C supplementation and improved bone mineral density [18-20].

Vitamin C has a tremendous impact on bone, including restoring normal development of critical bone-forming cells (osteoblasts) [21].

 

May Help Boost Mood

Several mechanisms are being explored to explain vitamin C’s mood-improving effects — beyond its ability to combat oxidative stress.

One recent animal study showed that vitamin C may activate receptors for the neurotransmitter GABA, which boosts mood [25]. Another provided evidence that vitamin C modulates human opioid-like receptors as it exerts its anti-depressant effects [26].

 

Summary

Multiple, large studies have shown that individuals with higher blood levels of vitamin C are less likely to die from any cause. Vitamin C has important preventive effects on a range of age-associated health issues.

Daily vitamin C supplementation plays a vital role in optimizing our body’s ability to combat oxidative stress and protect against many of the health issues associated with aging.

 

You can find more information about our wide range of Vitamin C products here.

 

References

  1. Aumailley L, Dubois MJ, Brennan TA, et al. Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein. FASEB J. 2018 Jul;32(7):3623-40.
  2. Aumailley L, Warren A, Garand C, et al. Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice. Aging (Albany NY). 2016 Mar;8(3):458-83.
  3. Son YS, Ullah HMA, Elfadl AK, et al. Preventive Effects of Vitamin C on Diethylnitrosamine-induced Hepatotoxicity in Smp30 Knockout Mice. In Vivo. 2018Jan-Feb;32(1):93-9.
  4. Dallaire A, Proulx S, Simard MJ, et al. Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span. BMC Genomics. 2014Oct 27;15:940.
  5. Dietrich M, Block G, Benowitz NL, et al. Vitamin C supplementation decreases oxidative stress biomarker f2-isoprostanes in plasma of nonsmokers exposed to environmental tobacco smoke. Nutr Cancer.2003;45(2):176-84.
  6. Mazloom Z, Hejazi N, Dabbaghmanesh MH, et al. Effect of vitamin C supplementation on postprandial oxidative stress and lipid profile in type 2 diabetic patients. Pak J Biol Sci. 2011Oct 1;14(19):900-4.
  7. Sumanasekera WK, Dao HT, Shekhovtsova V, et al. The mechanistic role of oxidative stress in cigarette smoke-induced cardiac stem cell dysfunction and prevention by ascorbic acid. Cell Biol Toxicol. 2018Jul 13.
  8. Stadler N, Eggermann J, Voo S, et al. Smoking-induced monocyte dysfunction is reversed by vitamin C supplementation in vivo. Arterioscler Thromb Vasc Biol. 2007Jan;27(1):120-6.
  9. Ashor AW, Lara J, Mathers JC, et al. Effect of vitamin C on endothelial function in health and disease: a systematic review and meta-analysis of randomised controlled trials. 2014 Jul;235(1):9-20.
  10. Gorton HC, Jarvis K. The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections. J Manipulative Physiol Ther. 1999Oct;22(8):530-3.
  11. Strohle A, Hahn A. [Vitamin C and immune function]. Med Monatsschr Pharm. 2009Feb;32(2):49-54; quiz 5-6.
  12. Strohle A, Wolters M, Hahn A. Micronutrients at the interface between inflammation and infection--ascorbic acid and calciferol: part 1, general overview with a focus on ascorbic acid. Inflamm Allergy Drug Targets. 2011Feb;10(1):54-63.
  13. Carr AC, Maggini S. Vitamin C and Immune Function. 2017 Nov 3;9(11).
  14. Manning J, Mitchell B, Appadurai DA, et al. Vitamin C promotes maturation of T-cells. Antioxid Redox Signal. 2013Dec 10;19(17):2054-67.
  15. Uchio R, Hirose Y, Murosaki S, et al. High dietary intake of vitamin C suppresses age-related thymic atrophy and contributes to the maintenance of immune cells in vitamin C-deficient senescence marker protein-30 knockout mice. Br J Nutr. 2015Feb 28;113(4):603-9.
  16. Chen Y, Luo G, Yuan J, et al. Vitamin C mitigates oxidative stress and tumor necrosis factor-alpha in severe community-acquired pneumonia and LPS-induced macrophages. Mediators Inflamm. 2014;2014:426740.
  17. de la Fuente M, Ferrandez MD, Burgos MS, et al. Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol. 1998Apr;76(4):373-80.
  18. Hall SL, Greendale GA. The relation of dietary vitamin C intake to bone mineral density: results from the PEPI study. Calcif Tissue Int. 1998Sep;63(3):183-9.
  19. Chuin A, Labonte M, Tessier D, et al. Effect of antioxidants combined to resistance training on BMD in elderly women: a pilot study. Osteoporos Int. 2009Jul;20(7):1253-8.
  20. Ruiz-Ramos M, Vargas LA, Fortoul Van der Goes TI, et al. Supplementation of ascorbic acid and alpha-tocopherol is useful to preventing bone loss linked to oxidative stress in elderly. J Nutr Health Aging. 2010 Jun;14(6):467-72.
  21. Gabbay KH, Bohren KM, Morello R, et al. Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis. J Biol Chem. 2010Jun 18;285(25):19510-20.
  22. Findik RB, Ilkaya F, Guresci S, et al. Effect of vitamin C on collagen structure of cardinal and uterosacral ligaments during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2016Jun;201:31-5.
  23. Panwar P, Butler GS, Jamroz A, et al. Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases. Matrix Biol. 2018Jan;65:30-44.
  24. Wilson S, Guilbert M, Sulé-Suso J, et al. The effect of collagen ageing on its structure and cellular behavior.Vol 82222012.
  25. Moritz B, Schwarzbold ML, Guarnieri R, et al. Effects of ascorbic acid on anxiety state and affect in a non-clinical sample. Acta Neurobiol Exp (Wars). 2017;77(4):362-72.
  26. Rosa PB, Neis VB, Ribeiro CM, et al. Antidepressant-like effects of ascorbic acid and ketamine involve modulation of GABAA and GABAB receptors. Pharmacol Rep. 2016Oct;68(5):996-1001.
  27. Zhu LL, Cao J, Sun M, et al. Vitamin C prevents hypogonadal bone loss. PLoS One. 2012;7(10):e47058.

 

 

 

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