Super fruits non-GMO Pomegranate Gluten-free

Endothelial Defense™ Pomegranate Plus

Heart health support starts with your blood vessels

Item #02497 60 Softgels 2 per serving In Stock
Super fruits non-GMO Pomegranate Gluten-free

Endothelial Defense™ Pomegranate Plus

Heart health support starts with your blood vessels

Item #02497 60 Softgels 2 per serving In Stock

For you, if you are looking to maintain cardiovascular health by protecting endothelial cells that line your blood vessels

The active ingredients in Endothelial Defense Pomegranate Plus can:
  • Support endothelial cell health and function with pomegranate seed, flower and fruit extract
  • Help maintain blood vessel and circulatory health with Cardiose® sweet orange peel extract
  • Encourage natural antioxidant production with new Extramel® melon pulp concentrate

A thin layer of cells that line the insides of your blood vessels called the vascular endothelium is absolutely essential to your cardiovascular health.


Content: 60 Softgels
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Product details "Endothelial Defense™ Pomegranate Plus"
Health benefits at a glance:

Pomegranate polyphenols provide metabolic and cardiovascular support—including for your vascular endothelium. Endothelial Defense Pomegranate Plus combines over 500 mg of standardized pomegranate extracts: POMELLA® pomegranate fruit extract, which is standardized to 30% punicalagin, and a proprietary blend of pomegranate flower extract and pomegranate seed oil standardized to 22% punicic acid.

Why it works:

The endothelial layer of your blood vessels plays an important role in regulating the health of your cardiovascular system—and with it, things like blood pressure, circulatory health and more. As you age, protecting the endothelium is critical for maintaining overall health—and Endothelial Defense Pomegranate Plus combines three nutrients that do just that.

Pomegranate seed, fruit and flower extracts

Pomegranate is a potent source of polyphenol extracts. These polyphenol compounds have valuable health benefits, including promoting healthy endothelial function, inhibiting oxidative stress, supporting metabolic and cardiovascular health and promoting a healthy inflammatory response.1-11 Endothelial Defense Pomegranate Plus contains standardized extracts from pomegranate flower and fruit, as well as extract of pomegranate seed oil.

Melon concentrate promotes antioxidant production

Extramel® is a concentrate of a special variety of a French melon. It encourages the body to produce superoxide dismutase (SOD), a potent inhibitor of oxidative stress.12,13 In pre-clinical models, consuming Extramel® melon concentrate increased SOD levels in various organ tissues.14

Extramel® appears to support the overall quality of life as well. In not one, but two studies, subjects consuming 10 mg a day of this melon concentrate reported decreased feelings of general fatigue. Healthy stress response and increased feelings of well-being were reported as well.15,16

The science behind the product:

Clinically-studied compound from sweet orange peels

There is a compound derived from citrus peels called hesperetin. Hesperetin has been found to promote endothelial production of nitric oxide, which encourages vasodilation—a key requirement for healthy circulation. Cardiose® sweet orange peel extract is standardized to be 90% hesperetin-7-O-rutinoside 2S, an easily absorbed kind of hesperetin.17

In a randomized controlled trial, 500 mg of sweet orange peel extract produced a 20% improvement in flow-mediated dilation, an indicator of healthy endothelial function. This extract also promoted a healthy inflammatory response.18

How to use:
  • Take two (2) softgels daily before breakfast, or as recommended by a healthcare practitioner
Health topics:
Supplement Facts

Serving size 2 softgel

Amount per serving:
Calories 20
Total Fat 1.5 g
Total Carbohydrate 1 g
Protein < 1 mg
Cardiose® flavonoid glycoside [from immature sweet orange (peel)] [std. to 90% rutinoside] 500 mg
POMELLA® pomegranate extract (fruit) [std. to 30% punicalagins] 400 mg
Proprietary pomegranate blend (flower extract and seed oil) [std. to 22% punicic acid] 137,5 mg
Pomegranate 5:1 extract (fruit) 100 mg
Extramel® melon pulp concentrate (fruit) [providing 500 IU of SOD enzyme activity] 36 mg

Other ingredients: extra virgin olive oil, gelatin, glycerin, sunflower lecithin, purified water, beeswax, carob color, dextrin.


Cardiose® is a registered trademark of INTERQUIM, S.A. d.b.a. Ferrer HealthTech. POMELLA® Extract is covered under U.S. Patent 7,638,640 and POMELLA® is a registered trademark of Verdure Sciences, Inc.

Extramel® is a registered trademark of Bionov.

Dosage and use:

Take two (2) softgels daily before breakfast.


Keep out of reach of children.

Do not exceed recommended dose.

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store tightly closed in a cool and dry place.

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  2. Phytother Res. 2017;31(11):1731-1738.
  3. Journal of the science of food and agriculture. 2017;97(6):1798-1804.
  4. Complementary therapies in clinical practice. 2016;22:44-50.
  5. Journal of medicinal food. 2015;18(9):941-949.
  6. Plant foods for human nutrition (Dordrecht, Netherlands). 2015;70(1):9-14.
  7. Plant foods for human nutrition (Dordrecht, Netherlands). 2012;67(4):351-357.
  8. lant foods for human nutrition (Dordrecht, Netherlands). 2012;67(3):309-314.
  9. Frontiers in pharmacology. 2018;9:544.
  10. Journal of nutritional science. 2012;1:e9.
  11. Journal of nutritional science. 2017;6:e39.
  12. Biochimica et biophysica acta. 2010;1804(2):245-262.
  13. Food Nutr Res. 2016;60:32729.
  14. Food Nutr Res. 2016;60:32729-32729.
  15. Nutrients. 2014;6(6):2348-2359.
  16. Nutr J. 2009;8:40.
  17. Agro Food Industry Hi Tech. 2015;26(4):6-10.
  18. Cordiart. Vol 12019:1-2.
Original source/product from Life Extension®