Health benefits at a glance:

Pomegranate polyphenols provide metabolic and cardiovascular support, including for your vascular endothelium. 

Endothelial Defense™ Pomegranate Plus combines hesperidin and a melon concentrate with over 500 mg of standardized pomegranate extracts: 

• POMELLA® pomegranate fruit extract, which is standardized to 30% punicalagin
• A proprietary blend of pomegranate flower extract
• Pomegranate seed oil standardized to 22% punicic acid

Why it works:

The endothelial layer of your blood vessels plays an important role in regulating the health of your cardiovascular system, and with it, things like blood pressure, circulatory health and more. 

As you age, protecting the endothelium is critical for maintaining overall health and an often-overlooked part of your cardiovascular and circulatory systems.

Endothelial Defense™ Pomegranate Plus provides three botanical ingredients rich in flavonoids and polyphenols to support the vascular endothelium.

The science behind the product:

Pomegranate seed, fruit, and flower extracts

Pomegranate is a potent source of polyphenol extracts. These polyphenol compounds have valuable health benefits, including promoting healthy endothelial function, inhibiting oxidative stress, supporting metabolic and cardiovascular health and promoting a healthy inflammatory response. (1-11) 

Endothelial Defense Pomegranate Plus contains standardized extracts from pomegranate flower and fruit, as well as extract of pomegranate seed oil.

Melon concentrate can promote antioxidant production

Extramel® is a concentrate of a special variety of a French melon. It encourages the body to produce superoxide dismutase (SOD), a potent inhibitor of oxidative stress. (12,13) 

In pre-clinical models, consuming Extramel® melon concentrate increased SOD levels in various organ tissues. (14)

Extramel® appears to support the overall quality of life as well. In not one, but two studies, subjects consuming 10 mg a day of this melon concentrate reported decreased feelings of general fatigue. Healthy stress response and increased feelings of well-being were reported as well. (15,16)

Clinically-studied compound from sweet orange peels

There is a compound derived from citrus peels called hesperetin. Hesperetin has been found to promote endothelial production of nitric oxide, which encourages vasodilation, a key requirement for healthy blood flow. 

Cardiose® sweet orange peel extract is standardized to be 90% hesperetin-7-O-rutinoside 2S, an easily absorbed kind of hesperetin. (17)

In a randomized controlled trial, 500 mg of sweet orange peel extract produced a 20% improvement in flow-mediated dilation, an indicator of healthy endothelial function. This extract also promoted a healthy inflammatory response. (18)

How to use:

• Take two (2) softgels daily before breakfast, or as recommended by a healthcare practitioner