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Item #01913 5000 mcg 30 Vegetarian Tablets 1 per serving In stock Share Add to Wishlist
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Health Benefits at a Glance:

The active form of folate, 5-methyltetrahydrofolate(5-MTHF) found in High Potency Optimized Folate (L-Methylfolate) can help maintain healthy homocysteine levels. Normal homocysteine levels promote normal cardiovascular- and nervous system function.


Why it Works:

Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the entire human body. However, certain people taking folate supplements, may not be enjoying all the health benefits associated with folate. This is because not all people can convert folate to its biologically active form called 5-methyltetrahydrofolate (5-MTHF) [1].  In turn, this leaves these people vulnerable to low blood folate levels and higher-than-desired homocysteine. People with higher-than-normal homocysteine levels have a greater risk of experiencing cognitive decline [2].

5-MTHF is able to cross the blood-brain barrier, which is highly important for people who suffer from cognitive difficulties. This is because 5-MTHF actively enhances the synthesis of a neurotransmitter (acetylcholine) associated with memory.  That is the reason why a vegetarian tablet of High Potency Optimized Folate (L-Methylfolate) provides 5,000 mcg of the bioactive 5-MTHF form of folate which is up to 7 times more bioavailable than ordinary folic acid and can help bring homocysteine levels back to normal levels, promoting cognitive, nervous and cardiovascular health.


The Science Behind the Product:

Research demonstrates that in many people, deficiency of genetic enzymes does not allow the conversion of folate to 5-MTHF.

5-MTHF has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been revealed to dramatically elevate red blood cell folate levels [3] compared to folic acid supplementation.

This bioactive folate is up to seven times more bioavailable than folic acid. In addition, it does not require conversion to become metabolically active and is therefore particularly vital in people who experience a genetic enzyme deficiency [4]

Studies also report that the effectiveness of 5-MTHF can be further increased by co-supplementing with methylcobalamin (the active form of vitamin B12),[5] vitamin B6, and riboflavin [5].


How to Use:

  • Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.


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Supplement Facts

Serving Size 1 vegetarian tablet

Amount Per Serving

Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt]

5000 mcg

Other ingredients: microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, vegetable stearate.


Dosage and Use
  • Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.

Do not use this product if treated with methotrexate, fluorouracil, phenytoin, phenobarbital, primidone, or levodopa prior to consultation with your personal physician.

  • Keep out of reach of children.
  • Do not exceed recommended daily dose.
  • Do not purchase if outer seal is broken or damaged.
  • If you are undergoing treatment for a medical condition or if you are pregnant or lactating, please consult your medical practitioner first.
  • A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
  • Store tightly closed in a cool, dry place.


  1. Proc Natl Acad Sci U S A. 2009; 106(36): 15424–15429.
  2. N Engl J Med. 2002 Feb 14;346(7):476-83.
  3. Am J Clin Nutr. 2006 Jul;84(1):156-61.
  4. Br J Pharmacol. 2004 Mar;141(5):825-30.
  5. Clin Chem. 2000 Aug;46(8 Pt 1):1065-71.

High Potency Optimized Folate (L-Methylfolate):


  • Supports cardiovascular health
  • Supports nervous system function
  • Maintains healthy homocysteine levels


5-methyltetrahydrofolate (5-MTHF), which is the active form of folate, helps to maintain healthy homocysteine levels, which in turn can lead to better cardiovascular and nervous system function. 


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