Vegetarian non-GMO General Immune Support Reishi

Immune Senescence Protection Formula™

"Best-in class" support for the immune systems

Item #02005 60 Vegetarian Capsules 2 per serving In Stock
Vegetarian non-GMO General Immune Support Reishi

Immune Senescence Protection Formula™

"Best-in class" support for the immune systems

Item #02005 60 Vegetarian Capsules 2 per serving In Stock

For you, if you want an innovative formula with comprehensive immunity support

The ingredients in Immune Senescence Protection Formula™ can:

  • Inhibit immune senescence by supporting a healthy ratio of naïve-to-memory T cells
  • Encourage youthful immune response by triggering immune cell development & activity
  • Promote the first line of defense by supporting natural killer (NK) cell response
  • Help maintain bone marrow health & longevity

Immune Senescence Protection Formula™ contains cistanche, reishi mushroom, and pu-erh tea extract and focuses on supporting three types of immune cells: naïve T cells, memory T cells and natural killer (NK) cells.

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Product details "Immune Senescence Protection Formula™"
Health benefits at a glance:

Immune Senescence Protection Formula™ can provide comprehensive immune senescence protection and was created for year-round support of the immune systems.

Why it works:

Due to age, our immune system declines. An imbalance between certain immune cell populations develops, involving a surplus of so-called memory T cells that go after known invaders and a deficit of so-called naïve T cells that attack new invaders.

The final result is a less-vigilant defense system – or immune senescence, which contributes to the problems of aging.

Life Extension® researchers have designed an innovative formula to help rebalance the major arms of the aging immune system. Immune Senescence Protection Formula™ provides three potent immune supporting ingredients cistanche, reishi mushroom, and pu-erh tea extract .

The science behind the product:

This formula focuses on supporting three types of immune cells: naïve T cells, memory T cells and natural killer (NK) cells. Naïve T cells attack new invaders. (1) Memory T cells attack previously-known invaders. (2) NK cells function as your body’s first responders. (3) 

When a naïve T cell encounters a new threat, it remembers it, becoming a memory T cell. This means we naturally develop a surplus of memory T cells over time. (4) 

In order to maintain a healthy immune system, we need to support a youthful ratio of naïve to memory T cells, promote healthy naïve T cell production, and encourage NK cell activity.

Rejuvenating the immune system with cistance 

The cistanche plant contains a compound called echinacoside. It can stimulate naïve T cell development, which in turn supports a healthy ratio of naïve-to-memory T cells. (5,6) 

Cistanche can also increase NK cell activity. In pre-clinical research, cistanche supported a 15% life span increase for NK cells. (5)

In a 12-week clinical study, standardized cistanche produced an 11.7% increase in NK cell activity and a 20.2% improvement in the ratio of CD4 to CD8 cells, an indicator of youthful, healthy immune response. (7)

Inhibiting immune senescence with reishi mushroom

Pre-clinical research indicates that reishi mushroom's bioactive compounds may help inhibit the factors of immune senescence and promote longevity. (8,9)  These extracts strengthen the immune system’s first line of defense by boosting the function of innate immune cells.

This species is packed with polysaccharides, triterpenes and other compounds that boost the function of hematopoietic stem cells, T cells and other essential immune factors that serve as your body’s defense, thus inhibiting immune senescence and promoting longevity.  (8,10)

Supporting immune balance with pu-erh tea extract

Pu-erh tea is made from the same plant as black and green tea. Although, this kind of tea is different; it’s rich in polyphenols and other bioactive molecules that support immune health.

In a pre-clinical study, pu-erh extract produced a 7% increase in NK cells and a 10% increase in naïve T cells. 

In the same study, pu-erh tea extract promoted healthy bone marrow function, which helps rebuild peripheral immune cell components. (11)

How to use:

Please take according to the dosage and use guidelines under supplement facts, or as recommended by a healthcare practitioner.

Health topics:
Supplement Facts

Serving size 2 vegetarian tablets

Servings per container 30

Amount per serving

Calcium (as calcium carbonate)

175 mg

Reishi mushroom extract (fruit body) [std. to 13.5% polysaccharides, 6% triterpenes]

980 mg

Pu-erh tea extract (leaf) [providing polyphenols, theabrownin]

650 mg

Cistanche tubulosa extract (stem and leaf) [std. to 22% echinacosides]

210 mg

Shell-broken reishi mushroom (spore)

150 mg

Other ingredients: microcrystalline cellulose, starch, croscarmellose sodium, stearic acid, aqueous film coating (hypromellose, glycerin, purified water), hydroxypropyl cellulose, maltodextrin, silica, vegetable stearate.


Dosage and use
  • Take two (2) tablets daily with food, or as recommended by a healthcare practitioner.
  • Each serving contains approximately 32.5 mg of caffeine (the amount found in about a 3/4 cup brewed green tea).

Do not purchase if outer seal is broken or damaged.
If you are undergoing treatment for a medical condition or if you are pregnant or lactating, please consult with your medical practitioner first.


A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store tightly closed in a cool and dry place.

  1. Immunol Rev.2018;285(1):218-232.
  2. Immunity. 2018;48(2):214-226.
  3. Front Immunol.2018;9:1869-1869.
  4. Inflamm Regen.2018;38:24-24.
  5. Evid Based Complement Alternat Med. 2014;2014:601383-601383.
  6. Aging Dis.2017;8(6):740-759.
  7. Anti-Aging Medicine. 2011;8(2):7-14.
  8. Tumor Biology. 2016;37(3):2789-2804.
  9. Int J Med Mushrooms.2011;13(5):441-448.
  10. Am J Chin Med.2011;39(01):15-27.
  11. Food Chem.2012;135(4):2222-2228.

Original source/product from Life Extension®