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Item #01868EU 120 Capsules 4 per serving In stock Share Add to Wishlist
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Health Benefits at a Glance:

Known as "cellular dynamos," healthy mitochondria produce the energy that power cells. As people age, however, mitochondria both lose function and decrease in number. Life Extension's unique Mitochondrial Energy Optimizer with PQQ was formulated to enhance mitochondrial function, protect delicate cellular structures, power-charge metabolic processes and aid in the creation of new mitochondria.


Why it Works:

Mitochondria are the powerhouses of the human cells because they produce cellular energy. Cells require healthy mitochondrial activity to perform life-sustaining metabolic processes. As mitochondrial function weakens, so does the vitality of organs, like heart and brain or, in some cases, the entire body.

Besides mitochondrial decay, ageing is characterized by glycation, and loss of cellular function/structure. Mitochondrial Energy Optimizer with PQQ brings together potent nutrients in one formula to help neutralize these changes.


The Science Behind the Product:

Researchers have identified a number of compounds that can help mitochondria function more efficiently and even help generate new mitochondria. The following unique ingredients in Mitochondrial Energy Optimizer with PQQ have all been shown to benefit mitochondria:

  • PQQ (Pyrroloquinoline quinone) - next generation cellular rejuvenator that triggers growth of new mitochondria in ageing cells and helps with protecting their delicate structures.
  • Carnosine - a powerful agent that works against damaging glycation reactions and protects neurons against toxic so called protein carbonyl species associated with normal ageing.
  • Thiamine – or vitamin B1 which plays a vital role in glucose metabolism and supports energy generation from food.
  • Pyridoxal 5'-Phosphate - the active form of vitamin B6 that has been shown to help protect against glycation, a toxic process involved in accelerated ageing. 
  • R-Lipoic Acid - a potent form of lipoid acid that promotes mitochondrial bioenergetics and lessens the impact of free radicals.
  • Taurine. This amino acid supports neurite growth50 and powerfully protects the mitochondria51 from oxidative damage to enhance energy production within cells.50,52,53  Taurine is prevalent throughout the body54 and found in especially high amounts in the metabolically active cells that require high mitochondrial energy production (brain,54 nerve, eye,55 heart,56 and skeletal muscle cells57).


Please note: This formulation has been aligned with EU ingredient standards for food supplements, ensuring the highest possible ingredient potency allowed in the Netherlands and other countries of the EU.


How to Use:

  • Take two (2) capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner.
  • This product can be taken with or without food.


Reference List:

  1. J Biol Chem. 2010. Jan 1;285:142-52.
  2. Alt Med Rev. 2009; 14(3):268-77.
  3. Entrez Gene: PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [ Homo sapiens ] GeneID: 10891.
  4. Entrez Gene: CREBBP CREB binding protein [ Homo sapiens ] GeneID: 1387.
  5. Exp Gerontol. 2015 Jun;66:1-9.
  6. Eur Spine J. 2015 Aug;24(8):1702-10.
  7. Diabetologia. 2002 Oct;45(10):1457-62.
  8. Pathol Biol (Paris). 2003 Dec;51(10):543-9.
  9. Brain Res Rev. 2003 Mar;41(2-3):306-23.
  10. Arthritis Rheum. 2004 Apr;50(4):1207-15.
  11. Med Hypotheses. 2004;62(2):275-9.
  12. Can J Physiol Pharmacol. 2000 Oct;78(10):848-55.
  13. Ann N Y Acad Sci. 2001 Apr;928:48-53.
  14. Arthritis Rheum. 2002 Jan;46(1):114-23.
  15. J InvestDermatol. 2002 Aug;119(2):489-98.
  16. Kurume Med J.2002;49(1-2):7-13.
  17. Curr Pharm Des. 2008;14(10):946-52.
  18. J Alzheimers Dis. 2007 May;11(2):229-40.
  19. Curr Clin Pharmacol.2011 Nov;6(4):236-59.
  20. Ann N Y Acad Sci. 2006 May;1067:369-74.
  21. Eur J Pharmacol. 2011 Jan 10;650(1):184-94.
  22. Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12.
  23. Neurobiol Aging. 2014 Jun;35(6):1469-72.
  24. Atherosclerosis. 2014 Feb;232(2):403-9.
  25. Life Sci. 2007 Nov 30;81(23-24):1602-14.
  26. J Nutr. 2006 Jun;136(6):1517-21.
  27. J Neuroinflammation. 2008 Sep 25;5:41.
  28. Immunology. 2005 Jul;115(3):375-87.
  29. Am J Respir Crit Care Med. 2002 Mar 15;165(6):818-23.
  30. Eur J Pharmacol. 2006 Jul 10;541(1-2):95-105.
  31. Neurosci Lett. 2008 Dec 26;448(2):175-9.
  32. Biochimie. 2011 Mar;93(3):506-12.
  33. J Pharmacol Exp Ther. 2011 Sep;338(3):1013-22.
  34. Int J Neurosci. 2011 Jun;121(6):329-36.
  35. Nat Med. 2003 Mar;9(3):294-9.
  36. J Am Soc Nephrol. 2011 May;22(5):914-26.
  37. Pharmacol Res. 2010 Jun;61(6):482-8.
  38. Diabetes Care. 2006 Sep;29(9):2064-71.
  39. Circ Heart Fail. 2010 Mar;3(2):294-305.
  40. Acta Diabetol. 2001;38(3):135-8.
  41. J Pak Med Assoc.2012 Oct;62(10):1033-8.
  42. Acta Diabetol. 2012 Dec;49 Suppl 1:S141-51.
  43. Genes Nutr. 2012 Jul;7(3):459-69.
  44. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7.
  45. Biochem Biophys Acta. 2001 Feb.14;1535(2):110-9.
  46. J Lipid Res. 2006 May; 47(5): 964-74.
  47. J Am Soc Nephrol. 2005 Jan;16(1):144-50.
  48. Life Sci. 1988;43(21):1725-31.
  49. Amino Acids. 2012 Apr;42(4):1163-70. 
  50. Amino Acids. 2015 Apr;47(4):735-44.
  51. Mol Vis. 2012; 18: 2673–2686.
  52. Neurosci Lett. 2015 Mar 17;590:52-7.
  53. Adv Exp Med Biol. 2015;803:397-405.
  54. Adv Exp Med Biol. 2015;803:409-13.
  55. Prog Retin Eye Res. 2014 Jul;41:44-63.
  56. Am J Physiol Heart Circ Physiol. 2015 Feb 1;308(3):H232-9.
  57. J Transl Med. 2015 Jul 25;13:243.



Learn more...

Servings Per Container 30

Amount Per Serving (4 capsules):

Vitamin B6 (as pyridoxal 5’-phosphate)

20 mg


1000 mg


800 mg

Vitamin B1 (as thiamine HCl)

150 mg

R-Lipoic Acid (as microencapsulated Bio-Enhanced® stabilized Na-RALA sodium R-lipoate)

150 mg

PQQ Pyrroloquinoline quinone disodium salt

10 mg

Other ingredients: capsule (glazing agent: hydroxypropylmethylcellulose), microcrystalline cellulose, stearic acid, silica, hydroxypropyl cellulose, candelilla wax, beeswax, calcium silicate.

Bio-Enhanced® is a registered trademark of Geronova Research, Inc.

Dosage and Use
  • Take two (2) capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner.
  • This product can be taken with or without food.
Do not purchase if outer seal is broken or damaged.
If you are undergoing treatment for a medical condition or if you are pregnant or lactating, please consult with your medical practitioner first.
A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store tightly closed in a cool and dry place.


Can Help Energise Every Cell in Your Body

For you, if you are looking for a product that can support the body’s energy production

The active ingredients in Mitochondrial Energy Optimizer with PQQ can:


  • Support healthy mitochondrial function and cellular energy output
  • Trigger growth of new mitochondria in aging cells
  • Protect against glycation, a toxic process aggravated by elevated glucose levels which is involved in accelerated ageing. 
  • Aids in cellular metabolism of glucose



The ingredients in Mitochondrial Energy Optimizer with PQQ can support the mitochondria, which produces up towards 95% of the energy that the body needs (ATP), leaving you more energized.


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