Fight senescent cells and aging
Fight senescent cells and aging
For you, if you want to rejuvenate your cells and fight senescent cells
The active ingredients in Senolytic Activator® can:
- Help the body manage senescent cells
- Promote healthy and youthful cells
- Support body-wide rejuvenation
- Deliver a highly absorbable form of quercetin and fisetin at just three tablets a week
Senolytic Activator® combines black tea theaflavins and apigenin with a highly absorbable form of quercetin and fisetin to help the body manage senescent cells and promote youthful cells and longevity at the same time.
Health benefits at a glance:
Every person in the world has senescent (aging) cells in their body. The older you get, the more senescent cells you have. The senescent cells can gradually affect the functioning of healthy and youthful cells around them. Senolytic Activator contains a completely unique mix of theaflavins from black tea and quercetin that helps the body remove these senescent cells easily, help cellular rejuvenation and promote longevity.
Why it works:
Cellular senescence is a natural part of the aging process in which cells no longer function optimally. Senescent cells can accumulate over time, affecting the day-to-day function of the healthy cells around them.
Senolytic compounds selectively target senescent cells . New research indicates that black tea theaflavins and quercetin target specific biological pathways, making it easier for the body to manage senescent cells [2-4].
Moreover, senolytic research indicates that intermittent dosing in pre-clinical studies is effective at improving healthspan . That’s why Senolytic Activator instructions call for taking just three vegetarian capsules, once a week!
The science behind the product:
Senolytic Activator contains a unique combination of ingredients that offer a strategy for fighting senescent cells.
Theaflavin - helps reduce the senescent cell burden
Theaflavins are compounds derived from Camellia sinensis (tea plant). Theaflavins have widespread health benefits — supporting healthy cell division and healthy inflammatory response [5, 6].
New research indicates that theaflavins may be especially helpful for reducing senescent cell burden. In pre-clinical models, theaflavins helped powerfully inhibit the accumulation of particular cell senescence biomarkers. 
Quercetin - promotes cellular health
Quercetin supports endothelial and cardiovascular health, promotes healthy immune function and more [7, 8]. The value of quercetin has been recognized for some time. But its potential to meaningfully impact whole body rejuvenation is just starting to be uncovered through its senolytic activity. The discovery that quercetin is a senolytic compound has drawn significant attention to this unique approach to combat aging. 
Standard quercetin is hard to absorb. But this formulation features our new quercetin phytosome, a phospholipid sphere that encases the quercetin, aiding in its absorption and making it up to 50 times more bioavailable.
Easy-to-absorb fisetin - to boost longevity at the cellular level
Fisetin is terrific for whole-body health. It’s a powerful senolytic compound, meaning it actively target senescent cells, the ones that no longer function optimally. Fisetin helps encourage the body’s natural pathways for clearing senescent cells, which allows healthy cells to flourish. 
Another important aspect of cellular longevity is sirtuin function. Sirtuin proteins keep your cells performing at their best—but sirtuin activity declines with age.  Fisetin has been shown in preclinical studies to encourage youthful, healthy sirtuin function. [11-15]
But during digestion, much of fisetin is rapidly converted into other compounds by a process called conjugation. That’s why we protected fisetin by combining it with galactomannans, a type of fiber derived from fenugreek seed. Doing so makes it up to 25 times more readily available than standard fisetin.  That means it circulates in your system longer and your body has more time to access fisetin’s many health benefits.
Apigenin - a powerful addition
Life Extension has identified apigenin, a natural flavonoid, as a powerful addition to our Senolytic Activator® formula. Quercetin and theaflavins from black tea target senescent cells, but not all of them.
The remaining senescent cells create compounds known collectively as Senescence Associated Secretory Phenotype, or SASP.17 Apigenin helps inhibit remaining senescent cells from making SASP to support cellular and tissue health—a critical aspect of healthy aging. 
How to use:
Please take according to the dosage and use guidelines under supplement facts, or as recommended by a healthcare practitioner.
Serving size: 3 capsules
Servings per container: 12
|Amount per week (3 capsules):||%RI*|
|Bio-Fisetin Proprietary Blend Providing 18% fisetin (56 mg) [from wax tree extract (stem)], 35% galactomannans (109 mg) [from fenugreek (seed)]||312 mg||**|
|Theaflavins [from decaffeinated black tea extract (leaf)]||275 mg||**|
|Bio-Quercetin phytosome 25 mg quercetin [from Japanese sophora concentrate (flower bud)], phosphatidylcholine complex [from sunflower])||74 mg||**|
*RI = EU reference intake **No RI available
INGREDIENTS: wax tree extract (stem) (Toxicodendron succedaneum), fenugreek (seed) extract (Trigonella foenum-graecum L.), black tea extract (leaf) (Camellia sinensis L.), Japanese Sophora concentrate (flower, bud), phosphatidylcholine, apigenin, capsule (hydroxypropylmethylcellulose), sunflower lecithins, bulking agent (microcristalline cellulose/cross-linked cellulose gum), anti-caking agents (silicon dioxide (nano), magnesium salts of fatty acids)
Take three (3) capsules once weekly.
Keep out of reach of children.
Do not exceed recommended daily dose.
Do not purchase if outer seal is broken or damaged.
Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store tightly closed in a cool, dry place.
- Exp Gerontol. 2015 Aug; 68(19-25.
- Free Radic Biol Med. 2017 Dec; 113(59-70.
- Pharmacol Res. 2012 Oct; 66(4): 363-73.
- Aging Cell. 2015 Aug; 14(4): 644-58.
- Oxid Med Cell Longev. 2009 Nov-Dec; 2(5): 270-8.
- Cardiovasc Res. 2007 Jan 15; 73(2): 348-58.
- Nutrients. 2016 Mar 15; 8(3): 167.
- Trends Food Sci. Technol. 2016 56(October): 21-38.
- EBioMedicine. 2018;36:18-28.
- NPJ Aging Mech Dis. 2016;2:16017.
- Mini Rev Med Chem. 2018;18(13):1151-1157.
- Nutr Res Pract. 2017;11(5):430-434.
- Biochem Biophys Res Commun. 2015;467(4):638-44.
- Life Sci. 2018;193:171-179.
- Int Immunopharmacol. 2017;45:135-147.
- Akay Group. A cross over pilot pharmacokinetic study of Fisetin 1000mg and Formulated Fisetin 200 mg administered in a single dose to healthy volunteers. Unpublished study from supplier.
- Nat Med. 2015;21(12):1424-35.
- Biochem Pharmacol. 2015;96(4):337-48.