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SAMe, 200 mg, 30 tabs
Mood, joint, and liver support
Supplement Facts
For you, if you want to boost the levels of SAMe and support critical metabolic functions
The nutrients in SAMe can:
Help maintain a stable mood
Support liver health
Promote healthy joint function
SAMe occurs naturally in your body, and it participates in many essential metabolic functions by donating methyl groups to other molecules. Methyl groups need to be transferred between compounds to help with neurotransmitter signaling and protein function. The levels may decrease due to sickness and age.
What is SAMe?
SAMe (s-adenosyl-methionine) is an amino acid derivative. It occurs naturally in your body and is concentrated in the liver and brain. It is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids.
What does SAMe do?
SAMe is made naturally by your body and used in three important pathways:
Methylation: Contributing methyl groups to activate certain molecules. Methyl groups need to be transferred between compounds in the body to help with things like neurotransmitter signaling and protein function. (1,2)
Synthesis of polyamines: For cell growth, gene expression, neuronal regeneration, etc.
Transsulphuration: Synthesis of cysteine, glutathione and other sulphate chemicals.
Mood, liver & joint health
Several clinical studies have shown that SAMe can maintain the stability of mood. (3,4) It's required for the synthesis of norepinephrine, dopamine, and serotonin, and plays a role in other intracellular metabolic pathways.
Research has also demonstrated that SAMe can support joint function and comfort. (4,5)
SAMe is also found to promote liver health, which makes sense, since a significant portion of the body’s SAMe is produced in the liver. (6)
It contributes to the body’s antioxidant defenses by donating sulfur groups essential for producing glutathione, one of the body's most powerful natural antioxidants. (7)
However, SAMe levels tend to decrease with age. (8) Supplementing with SAMe can help support the many bodily functions that depend on this remarkable molecule’s biochemical activity.
Non-GMO | ||||||
Dosage and use: | ||||||
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Caution: | ||||||
SAMe should not be taken by those diagnosed with bipolar disorder. | ||||||
Warnings:
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- Am J Clin Nutr. 2002;76(5):1151s-7s.
- Annu Rev Biochem. 2016;85:485-514.
- J Clin Psychiatry. 2017;78(6):e656-e667.
- U.S. Department of Health and Human Services. S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease. Accessed May 23, 2019. https://archive.ahrq.gov/clinic/epcsums/samesum.htm
- Am J Med. 1987;83(5a):66-71.
- Ann Hepatol. 2013;12(2):183-9.
- Int J Biochem Cell Biol. 2000;32(4):391-5.
- J Gerontol. 1977;32(4):392-4.