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Item #00361 500 mcg 100 Lozenges 1 per serving In stock Share Add to Wishlist
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Health Benefits at a Glance:

Vitamin B12 (cobalamin) plays a role in supporting a healthy nervous system and promoting heart health because it contributes to maintaining homocysteine levels within the normal range. Supplementation with this vitamin can be especially important to those following a vegetarian diet and might also be more important to elderly people.


Why it Works:

Vitamin B12, or cobalamin, works together with folate and vitamin B6 to help maintain homocysteine levels within normal range. Maintaining normal homocysteine levels is in turn important for heart health [9-12].

Cobalamin serum levels are reported to be significantly lower in elderly population groups compared to younger ones [2-5]. It is estimated that 10% to 30% of individuals over the age of 50 have low stomach acid secretion [6-7] which results in decreased bioavailability of vitamin B12 from food, making it more difficult to maintain normal homocysteine levels and support heart health.

Vitamin B12 (cobalamin) is present in many different food sources of animal origin, including dairy products and eggs. Therefore, vegetarians are more susceptible to a dietary deficiency of this very important nutrient [1].

Cobalamin has also been shown to support nerve cell growth, cognition, and brain health in general. Together with folate it helps maintain the production of red blood cells within the normal range. Methylcobalamin is the bioactive form of B12 that is readily utilized by the body and the central nervous system.


The Science Behind the Product:

The Institute of Medicine indicates that requirements can be met much easier if fortified foods such as fortified ready-to-eat breakfast cereals or supplements containing this vitamin are used routinely by consumers [13].

Methylcobalamin (cobalamin), a form of this vitamin, has been shown to support neurological function and normal brain cell activity. Methylcobalamin has also been shown to prompt healthy cognitive, memory, and emotional function [14]. A deficiency of vitamin B12 can trigger the diminished synthesis of methionine synthase, the key enzyme responsible for the conversion of homocysteine to methionine. The result is a high level of serum homocysteine and a decreased level of methionine [15].


How to Use:

  • Take one (1) lozenge one to four times daily with or without food, or as recommended by a healthcare practitioner.
  • Place lozenge in mouth and allow to dissolve, then swallow.


Reference List:

  1. Exp Biol Med (Maywood). 2007 Nov;232(10):1266-74.
  2. Am J Clin Nutr. 2009 Feb;89(2):693S-6S.
  3. Prev Med. 2004 Dec;39(6):1256-66.
  4. Am J Clin Nutr. 1999;70:904-910.
  5. Am J Clin Nutr. 2008 Aug;88(2):348-55.
  6. JAMA. 1997 Aug 27;278(8):659-62.
  7. J Am Geriatr Soc. 1986 Nov;34(11):800-6.
  8. LE Magazine. Jul, 2004 “Vitamin B12”, link: http://www.lifeextension.com/Magazine/2004/7/aas/Page-01, accessed August 3rd 2017
  9. Lancet. 2002 Jan 19;359(9302):227-8.
  10. Asia Pac J Clin Nutr. 2007;16(1):103-9.
  11. Handb Exp Pharmacol. 2005;(170):325-38.
  12. Altern Med Rev. 2003 Feb;8(1):7-19.
  13. Epidemiology. 2007 May;18(3):367-8.
  14. Eur J Pharmacol. 1993 Sep 7;241(1):1-6.
  15. Neuroreport. 2003 Jul 18;14(10):1391-4.

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Serving Size 1 lozenge

Amount Per Serving

Vitamin B12 (as methylcobalamin)

500 mcg

Other ingredients: mannitol, sorbitol, microcrystalline cellulose, vegetable stearate, croscarmellose sodium, natural strawberry flavor.

Dosage and Use
  • Take one (1) lozenge one to four times daily with or without food, or as recommended by a healthcare practitioner. 
  • Place lozenge in mouth and allow to dissolve, then swallow.
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
  • A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store tightly closed in a cool, dry place.

Vitamin B12 Support for Brain and Heart Health

Vitamin B12:

  • Supports nervous system function and cognition
  • Promotes heart health by contributing to healthy homocysteine levels
  • Provides the bioactive B12 form methylcobalamin

Vitamin B12 is an essential nutrient which can promote heart health by contributing to normal homocysteine levels, and support brain health and cognition. 


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