For you, if you want to boost your body’s cellular recycling process
The nutrients in GEROPROTECT®Autophagy Renew can:
Offer an innovative anti-aging formula
Support optimal function of the body
Encourage healthy AMPK activity
Promote cells to recycle waste material
Help keep cellular energy balance
Support living your longest, healthiest life with GEROPROTECT® Autophagy Renew! This formula that can promote autophagy, which is the natural process for reusing cellular waste that can get in the way of healthy cell function.

Health benefits at a glance:
As we age, our bodies become less efficient at autophagy, which is the natural process that clears out cellular waste that can interfere with normal function.
Support this vital cellular clean-up process to help promote a longer, healthier life. GEROPROTECT® Autophagy Renew contains the plant flavonoid luteolin and piperlongumine, an alkaloid from pepper. Both these ingredients are shown to help maintain your body’s natural renewal system.
Why it works:
We all know recycling is good for the environment, but did you know it’s good for your cells too? Autophagy is the body’s natural process for clearing out intracellular waste and metabolic debris. Specialized cellular structures called lysosomes break down and repurpose this material.
Why is autophagy important? Because it helps your body conserve energy and maintain optimal function, which is key to encourage a long, healthy life. Geroprotect® Autophagy Renew help you with this!
The science behind the product:
Keep your cells clean and functioning
Without autophagy, our cells would become overwhelmed with waste, eventually losing their ability to function properly. The challenge is that autophagy naturally declines over time. But the right nutrients can encourage youthful, healthy autophagy at the cellular level, the hard part is figuring out which nutrients do the best job.
Powered by Insilico Artificial Intelligence
GEROPROTECT® Autophagy Renew was developed in collaboration with Insilico Medicine, Inc., using their extensive database of geroprotector research. Through advanced analysis they identified luteolin, sourced from the Japanese sophora flower, for its strong potential to promote autophagy. This has been further backed by several pre-clinical studies.
Life Extension® has added piperlongumine, a pepper alkaloid, because of their own extensive scientific review. Together, these nutrients have the potential to encourage healthy cellular autophagy – and with it, longevity.
Luteolin: The flavonoid for cellular renewal
Luteolin is a natural flavonoid found in fruits, vegetables, and nutritious herbs. While we get small amounts of luteolin from our diet, it’s far from enough to promote cellular renewal. GEROPROTECT® Autophagy Renew provides 165 mg of luteolin per serving. Pre-clinical studies show that luteolin promotes autophagy, leading toa variety of health benefits, particularly for brain health. (1)
Luteolin can support key cellular pathways, such as AMPK signaling, that encourages autophagy. It can also help generate new lysosomes, which is the "recycling plants" inside your cells that break down waste. (2) Additionally, can inhibit the processes that discourage autophagy, such as mTOR signaling, a central regulator of cellular metabolism and proliferation. (2)
Piperlongumine: A potent pepper alkaloid
Piperlongumine is an biologically active compound found in certain pepper plants. Pre-clinical research shows that it helps trigger autophagy. This was indicated by increased levels of LC3-autophagosomes, tructures involved in initiating autophagy within cells. (3,4)
Piperlongumine activates Beclin-1, which is a gene that plays a key role in the formation of these autophagosomes. (5) Beclin-1 dependent autophagy is shown to protect delicate mitochondria and help inhibit inflammation to support cardiovascular health. (5) This longevity supplement contains 10 mg of piperlongumine.
Take alone or with Senolytic Activator
While cellular housekeeping orchestrated by autophagy is a different process than the ones that govern the removal of senescent cells, they are complementary. Therefore, GEROPROTECT® Autophagy Renew can be taken alone, or in conjunction with Senolytic Activator formula.
How to use:
- Take one (1) capsule daily, or as recommended by a healthcare practitioner.
- Brain Res. 2014;1582:237-46.
- Insilico Medicine - Data on File
- Autophagy. 2018;14(5):845-861.
- Br J Cancer. 2014;110(4):899-907.
- Circulation. 2018;138(20):2247-2262.