Antioxidants non-GMO Gluten-free

Glutathione, 500 mg

Highly demanded reduced form, for powerful antioxidant support

Item #02521 60 Vegetarian Capsules 1 per serving In Stock
Antioxidants non-GMO Gluten-free

Glutathione, 500 mg

Highly demanded reduced form, for powerful antioxidant support

Item #02521 60 Vegetarian Capsules 1 per serving In Stock

For you, if you want to actively inhibit oxidation at the cellular level

The formula of Glutathione can:
  • Protect the cells from oxidative stress
  • Help in breaking down substances adding to oxidative stress
  • Function as a cofactor for multiple essential enzymes
  • Provide a gluten-free, vegetarian, non-GMO product

Glutathione is a compound in the body referred to as the “master antioxidant”. It has a very important job: helping protect your cells from oxidative stress. This powerful antioxidant exists in two different forms, including the oxidized and reduced states. In your body, the reduced (aka active) form of glutathione excels at scavenging for free radicals, effectively fulfilling its role as an antioxidant. The formula provides 500 mg per dose.

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Product details "Glutathione, 500 mg"
Health benefits at a glance:

First of all; what is glutathione? It’s an antioxidant compound in the body made up of three amino acids.

It’s a natural detoxifier and is nicknamed the “master antioxidant” – with good reasons! In your body, glutathione safeguards cells against oxidative stress and contributes to many other biochemical reactions.

This supplement offers 500 mg per dose of the requested reduced version of glutathione, which is the active form.

Why it works:

Glutathione holds many anti-aging benefits and is one of the most powerful antioxidant compounds in your body. 

However, glutathione levels decrease as you age, and natural production can also be slowed because of disease, medications, stress, trauma, infections, a poor diet, pollution, and radiation.

The reduced form of glutathione functions best as a free radical scavenger in your body, effectively fulfilling its role as an antioxidant.

So, if you want to protect yourself against oxidative stress and all its negative consequences, this reduced form of glutathione is a perfect complement to a wellness-oriented lifestyle.

The science behind the product:

The antioxidant benefits of glutathione

Your body produces glutathione with three amino acids: glycine, cysteine, and glutamate. (1) 

The reason it’s considered the body’s master antioxidant is because:

  • Glutathione protects cellular activity from within the cells. (1-3)
  • It regenerates/restores the activity of other antioxidants, helping them get back to their active forms, so they can continue their antioxidant functions. (1-3)
  • This antioxidant acts as a cofactor for many essential enzymes. (1-3)
  • Glutathione is also involved in the metabolism of certain compounds that can increase free radical activity, helping break down these compounds (that can cause oxidative stress). (4) 

The inactive versus active form (reduced glutathione)

In the body, glutathione exists in two forms: reduced and oxidized states. (5)

  1. When it’s in its reduced form, glutathione is actively scavenging for free radicals.
  2. When it’s oxidized, glutathione is inactive and cannot fulfill its role as an antioxidant.

Life Extension’s glutathione formula with 500 mg provides the active form of glutathione, meaning the reduced glutathione. 

What are free radicals and antioxidants?

In our daily lives, the body generates molecules known as free radicals, which circulate within. While they are normally the result of stress, various environmental factors such as smoke and pollutants can also trigger their formation.

When the body produces too many free radicals, it can cause oxidative stress – unwanted cellular reactions – which negatively impact the body and its cells. 

Antioxidants are substances that inhibit cellular-level oxidation. They function by neutralizing free radicals. 

Glutathione is outstanding at scavenging free radicals before they can cause cellular stress, thereby protecting the cells so they can function optimally.

How to use and FAQ:

Please take according to the dosage and use guidelines under supplement facts, or as recommended by a healthcare practitioner.

What is the dosage of this product?

This product provides 250 mg of reduced glutathione per capsule, and it’s suggested to take two capsules a day.

When is the best time to take Glutathione, 500 mg?

This product can be taken any time of the day, with or without food, based on your preference.

Will this supplement interact with my medication?

There is no indication that the glutathione in this formula would negatively interact with prescription medications. 

However, if you take any prescription medications and want to know more about potential interactions when taking this supplement, you should discuss supplementing with your physician.

Health topics:
Supplement Facts

Serving size: 2 capsules
Servings per container: 30

Amount per day (2 capsules):%RI*
Opitac® L-glutathione (reduced) 500 mg**

*RI = EU reference intake **No RI available


Glutathione, capsule (hydroxypropyl methyl cellulose), calcium phosphates, bulking agent (microcrystalline cellulose/cellulosegel)), anti-caking agents (silicon dioxide [nano], magnesium salts of fatty acids)


OPITAC® is the trademark for L-Glutathione of Mitsubishi Corporation Life Sciences Limited.


Take two (2) capsules daily.


  • Keep out of reach of children.
  • Do not exceed recommended daily dose.
  • Do not purchase if outer seal is broken or damaged.
  • Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
  • A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
  • Store tightly closed in a cool, dry place.
  1. J Nutr. 2004;134(3):489-92.
  2. Biochem Pharmacol. 2002;64(5-6):1019-26.
  3. Integr Med (Encinitas). 2014;13(1):8-12.
  4. Gupta, P. K. Fundamentals of Toxicology: Essential Concepts and Applications. 2016.
  5. Methods Mol Biol. 2010;648:269-77. 

Original source/product from Life Extension®