Circadian Sleep

Health benefits at a glance:

Circadian rhythms influence every aspect of health – from sleep patterns and heart rate to blood pressure, hormone release, brain function, and even weight regulation. Nearly every cell in our body has an internal “clock” that responds to changes in light perception and exposure, helping create our circadian rhythm and our own inner body clocks. '

When the circadian rhythm is brought out of balance, you not only have trouble sleeping. A circadian balance that is “out of tune” for longer periods of time can also affect your overall health negatively because good sleep and a healthy circadian rhythm are so essential to good health.

Circadian Sleep is a formula that uses a specially developed mix of melatonin and citrus peel extract to support normal circadian rhythms that help you sleep well and promote whole body health.

Why it works:

Your body clock (circadian rhythm) is best known for being an internal timekeeper that regulates your sleep-wake cycle. The body has two types of clocks that respond to this circadian rhythm, and they work together to manage all of the body’s systems:

1) The central clock in the brain controls sleep, wakefulness, body temperature, and hormones according to the time of day.

2) In addition, our individual cells contain a peripheral clock that regulates many critical biological processes, including liver function, blood pressure, new cell growth, and the release of hormones.

However, aging, a hectic lifestyle, and many other factors can contribute to the disruption of both of your circadian cycles. Over time, this can affect your overall health.

Circadian Sleep has been developed to help restore and reset both types of circadian rhythms, using two ingredients. While MicroActive® Melatonin targets the central body clock in your brain, nobiletin citrus peel extract can promote a healthy peripheral circadian rhythm in your organs. By using these two ingredients, Circadian Sleep can promote a body clock (circadian rhythm) in balance. Healthy sleep-wake cycles promote brain health and contribute to overall health.

The science behind the product:

Melatonin for central clock support

The central clock in the brain operates on light detected through the eyes. With the first light of day, our body turns on the systems, ready for activity. With the arrival of nightfall, our systems begin to shut down and prepare for sleep.

This activity is regulated in part through secretions of the sleep hormone melatonin from your brain’s pineal gland. This release of melatonin helps normalize hormone and neurotransmitter functions controlled by the brain and its central clock.

Science has shown that the hormone melatonin plays a critical role in keeping the central clock in sync with the environment and can restore our circadian rhythms through healthful sleep. The central clock, in turn, aligns the peripheral clock, which thereby also supports whole-body health. When melatonin output is inadequate, it can result in sleep trouble.

Nobiletin for healthy peripheral circadian rhythms

Almost all cells in your body have their own circadian rhythm. The cellular circadian rhythm is also known as the peripheral circadian clock. Its pace is being set by the central circadian rhythm because it regulates your sleep-wake cycles.

Nobiletin (a polyethoxylated flavone) is a compound that has been derived from the peel of young citrus fruits. Nobiletin is an interesting compound in relation to circadian rhythm support because it can activate a unique set of bodily regulators.

It has also been shown to offer antioxidant protection to brain cells, which promotes brain health. Furthermore, it has also been shown to promote a healthy inflammatory response in the body.

Pre-clinical studies have shown that nobiletin can help regulate peripheral circadian rhythms. It does so by activating unique receptors, which are known to play a role in regulating circadian rhythms, that exist throughout the body.

Nobiletin has also been shown to promote whole-body health. In another pre-clinical study, nobiletin helped regulate the expression of a certain set of genes. This particular set of genes helps control the expression of other genes that control circadian rhythms in almost every cell in the body.

This, in turn, supports a healthy metabolism, as well as liver, kidney, and brain health. It also helps maintain healthy blood pressure, cholesterol, and triglyceride levels.

How to use:

• Take one (1) capsule daily, before bedtime, or as recommended by a healthcare practitioner.
• Melatonin is naturally secreted from the pineal gland at night and should be taken at night for optimal results.