Vegan product Melatonin combi Melatonin

Circadian Sleep

Restore your body’s circadian rhythm with melatonin for better sleep and overall health

Item #02300 30 Liquid Vegetarian Capsules 1 per serving In Stock
Vegan product Melatonin combi Melatonin

Circadian Sleep

Restore your body’s circadian rhythm with melatonin for better sleep and overall health

Item #02300 30 Liquid Vegetarian Capsules 1 per serving In Stock

For you, if you want to your natural circadian rhythm for better sleep and overall health

The active ingredients in Circadian Sleep can:
  • Support a natural and healthy sleep-wake cycle
  • Help reset both your central and peripheral body clock (circadian rhythm)
  • Promote overall health through quality sleep and circadian rhythm support

The new and innovative Circadian Sleep formula combines melatonin with a unique citrus-peel extract and can support both “central” and “peripheral” body clock (circadian) functions [1-3]. This can help enhance high-quality sleep and promote overall health.

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Content: 30 Liquid Vegetarian Capsules
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Product details "Circadian Sleep"
Health benefits at a glance:

Your sleep-wake cycle is governed by your circadian rhythm, also known as your body clock. When the circadian rhythm is brought out of balance you are not only having trouble sleeping. 

A circadian balance that is “out of tune” for longer periods of time can also affect your overall health negatively because good sleep and a healthy circadian rhythm are so essential to good health.

Circadian Sleep is a novel formula that uses a specially developed mix of melatonin and citrus peel extract to support normal circadian rhythms that help you sleep well and promote whole body health.

Why it works:

Your body clock (circadian rhythm) is best known for being an internal timekeeper that regulates your sleep-wake cycle. However, few people know that there are actually two circadian rhythms: a central rhythm and a peripheral rhythm. 

The central circadian rhythm regulates sleep and other body functions such as temperature in accordance with the time of the day. In turn, the peripheral circadian rhythm regulates essential processes in your organs such as your heart rate, body temperature hormone release, blood pressure, liver and kidney function, pancreatic function and more [4-6].

However, aging, a hectic lifestyle and many other factors can contribute to the disruption of both of your circadian cycles. Over time this can affect your overall health [7-9].

Circadian Sleep has been developed to help restore and reset both types of circadian rhythms, using two ingredients. While MicroActive® Melatonin targets the central body clock in your brain, Nobiletin citrus peel extract promotes a healthy peripheral circadian rhythm in your organs.

By using these two ingredients, the Circadian Sleep formula not only promotes a body clock (circadian rhythm) in balance, it also supports healthy sleep-wake cycles, promotes brain health and contributes to overall health.

The science behind the product:

Melatonin supports the central clock function

Interestingly, almost all cells in your body have their own circadian rhythm. The cellular circadian rhythm is also known as the peripheral circadian clock. Its pace is being set by the central circadian rhythm because it regulates your sleep-wake cycles [1].

Melatonin is known as the sleep hormone because it helps ensure that the central clock is properly regulating sleep-wake cycles. It is produced naturally in your pineal gland, primarily when you are asleep [10]. 

The central clock, in turn, aligns the peripheral clock which thereby also supports whole body health. When melatonin output is inadequate, it can result in sleep trouble.

Nobiletin for healthy peripheral circadian rhythms

Nobiletin (a polymethoxylated flavone) is a compound which has been derived from the peel of young citrus fruits. Nobiletin is an interesting compound in relation to circadian rhythm support because it activates a unique set of bodily regulators. 

It has also been shown to offer antioxidant protection to brain cells which promotes brain health. Furthermore, it also has also shown to promote a healthy inflammatory response in the body [11]. 

Pre-clinical studies have shown that Nobiletin can help regulate peripheral circadian rhythms [2]. It does so by activating unique receptors which are known to play a role in regulating circadian rhythms [13-16] which exist throughout the body [12].

Moreover, Nobiletin has also been shown to promote whole body health. In another pre-clinical study, Nobiletin was shown to regulate the expression of a certain set of genes. This particular set of genes help control the expression of other genes that control circadian rhythms in almost every cell in the body [3].

This, in turn, supports a healthy metabolism, as well as liver, kidney and brain health. It also helps maintain healthy blood pressure, cholesterol and triglyceride levels [17-20].

How to use:
  • Take one (1) capsule daily, before bedtime, or as recommended by a healthcare practitioner.
  • Melatonin is naturally secreted from the pineal gland at night and should be taken at night for optimal results.
Health topics:
Supplement Facts

Serving size 1 liquid vegetarian capsule

Amount per serving:

Nobiletin [from young citrus fruit (peel)] 50 mg
Melatonin (as MicroActive®) 1.5 mg

Other ingredients: medium chain triglycerides, vegetable capsule (hydroxypropyl methylcellulose, chlorophyllin), microcrystalline cellulose, sodium alginate, carnuba wax, silica.


MicroActive® Melatonin is a registered trademark of Bioactives LLC.

Dosage and use:

Take one (1) capsule daily, before bedtime, or as recommended by a healthcare practitioner.

Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results.


Do not consume alcohol, drive or operate machinery after taking this product.


Keep out of reach of children.

Do not exceed recommended dose.

Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store tightly closed in a cool and dry place.

  1. Annu Rev Neurosci. 2012;35:445-62.
  2. PLoS One. 2017;12(2):e0170904.
  3. Cell Metab. 2016 Apr 12;23(4):610-21.
  4. Sleep Med Clin. 2015 Dec;10(4):413-21.
  5. Handb Exp Pharmacol. 2013 (217):3-27.
  6. Neuron. 2012 Apr 26;74(2):246-60.
  7. Curr Opin Insect Sci. 2015 Feb 1;7:82-86.
  8. Neurobiol Stress. 2017 Feb;6:57-67.
  9. Iran J Public Health. 2018 Aug;47(8):1068-1076.
  10. J Neuroendocrinol. 2003 Apr;15(4):432-7.
  11. Evid Based Complement Alternat Med. 2016;2016:2918796.
  12. Acta Pharmacol Sin. 2015 Jan;36(1):71-87.
  13. J Biol Rhythms. 2005 Oct;20(5):391-403.
  14. Nat Struct Mol Biol. 2005 May;12(5):441-8.
  15. Embo j. 1998 Jul 15;17(14):3867-77.
  16. Nucleic Acids Res. 2012 Sep 1;40(17):8519-35.
  17. Sleep Med Rev. 2012 Apr;16(2):151-66.
  18. Proc Nutr Soc. 2016 Nov;75(4):440-450.
  19. Front Mol Neurosci. 2012;5:50.
  20. Nat Rev Nephrol. 2018 Oct;14(10):626-635.

Original source/product from Life Extension®