07/12/2021

5 ways curcumin can help you stay healthy

Life Extension, curcumin turmeric powder and capsules with  a green plan to the right

Curcumin is perhaps one of the most omnipotent natural health ingredient there is. Derived from the turmeric root, curcumin is an ancient health remedy. 

In fact, it has been in use in Ayurvedic medicine for thousands of years. And that for a good reason. Its amount of health benefits is simply astonishing. 

The health benefits of this natural ingredient are so numerous that it ought to be a part of any serious supplementation program.

We have collected five of the many health benefits of this superfood: 


1. Curcumin is a powerful antioxidant

Over time, our cells will inadvertently be affected by free radicals which are compounds that can damage the cells. If free radicals are left to roam freely in the body they can contribute to chronic inflammation, aging acceleration, and more. 

Studies show that the antioxidant quality of curcumin can inhibit the impact of free radicals by scavenging the body for free radicals and neutralizing them. (1)


2. Curcumin can help you protect your brain

There are many factors that cause the brain to age. These include cumulative effects of oxidative stress, environmental toxins, inflammation, build up of toxic proteins and gradual damage of genes in individual cells. 

Curcumin may, however, help to protect against these factors in the brain. Furthermore, there are indications that curcumin can turn on genes responsible for triggering the emergence of new brain cells. (2-6)


3. Curcumin is good for your cardiovascular system

There is no doubt that exercise is good for the heart because it helps improve endothelial function – the functioning of the inner lining of blood vessels. 

Researchers have compared exercise to curcumin supplementation and found that it was just as good at improving endothelial function as regular exercise. 

Moreover, it also reduces the impact of high glucose and also helps normalize blood lipid profiles. (7)


4. Curcumin can promote your immune system

Curcumin can help enhance the body’s immune system in general. Numerous preclinical studies indicate curcumin may activate antiviral immunity, and it has demonstrated antiviral effects against a range of respiratory viruses. 

Curcumin also helps mitigate inflammation associated with the immune response to infection. (8-12)


5. Curcumin has great anti-aging properties

This superfood can help protect your genes in two ways. Because it is an antioxidant it prevents free radicals from inflicting damage on your DNA-strands. Simultaneously, it can also help to upregulate specific genes that help destroy cells with certain types of mutations.

Researchers are discovering that curcumin has anti-aging properties that can combat several key factors of aging. Studies show that curcumin can help: 

  • Eliminate senescent cells (13-15) 
  • Increase telomere length (16,17) 
  • Protect against glycation (18-22) 
  • Activate AMPK (23-25) 
  • Activate autophagy (26)  

In one animal study, it extended average lifespan by 26%. (27) The accumulating evidence indicates that curcumin helps stave off the aging process. (26,28,29)  


The solution for curcumin's poor oral bioavailability

The health benefits of this ingredient cannot be overstated. Curcumin has one drawback — poor oral bioavailability. Relatively little of ingested curcumin finds its way into the bloodstream. 

A method has been discovered that combines curcumin with a fiber derived from fenugreek seeds. Blood levels in people who received this curcumin encased in fenugreek fiber were 45 times greater than in those who took unformulated curcumin. (30,31)

Life Extension's proprietary Curcumin Elite™ formula preserves curcuminoids’ bioavailability, so you get the maximum possible benefit.

Scientists have discovered a way around this problem. By combining curcumin with a fiber called galactomannans, from the spice fenugreek, the curcumin is protected in the gut and resists metabolism.

The Life Extension's Curcumin Elite™ Turmeric Extract formula can preserve curcuminoids’ bioavailability, so you get the maximum possible benefit  45,5 times more bioavailable free curcuminoids as well as 270 times better absorption of curcuminoids than standard curcumin. 

The much higher bioavailability and absorption rates can enhance the many health benefits of curcumin supplementation.

Find all the curcumin supplements here >>

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References

  1. https://www.lifeextension.com/magazine/2014/2/bio-enhanced-turmeric-compounds-block-multiple-inflammatory-pathways
  2. Voulgaropoulou SD, van Amelsvoort T, Prickaerts J, et al. The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies. Brain Res. 2019 Dec 15;1725:146476.
  3. Yu Y, Shen Q, Lai Y, et al. Anti-inflammatory Effects of Curcumin in Microglial Cells. Front Pharmacol. 2018;9:386.
  4. Sunny A, Ramalingam K, Das S, et al. Bioavailable curcumin alleviates lipopolysaccharide-induced neuroinflammation and improves cognition in experimental animals. Pharmacognosy Magazine. 2019 April 1, 2019;15(62):111-7.
  5. Khanna A, Das SS, Kannan R, et al. The effects of oral administration of curcumin-galactomannan complex on brain waves are consistent with brain penetration: a randomized, double-blinded, placebo-controlled pilot study. Nutr Neurosci. 2020 Dec 9:1-10.
  6. Dong S, Zeng Q, Mitchell ES, et al. Curcumin enhances neurogenesis and cognition in aged rats: implications for transcriptional interactions related to growth and synaptic plasticity. PLoS One. 2012;7(2):e31211
  7. https://www.lifeextension.com/magazine/2017/10/curcumin-targets-cardiovascular-disorders
  8. Dai J, Gu L, Su Y, et al. Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways. International immunopharmacology. Jan 2018;54:177-187. doi:10.1016/j.intimp.2017.11.009
  9. Han S, Xu J, Guo X, Huang M. Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production. Clin Exp Pharmacol Physiol. Jan 2018;45(1):84-93. doi:10.1111/1440-1681.12848
  10. Obata K, Kojima T, Masaki T, et al. Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells. PLoS One. 2013;8(9):e70225. doi:10.1371/journal.pone.0070225
  11. Xu Y, Liu L. Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF-κB signaling pathway. Influenza Other Respir Viruses. Sep 2017;11(5):457-463. doi:10.1111/irv.12459
  12. Zuccotti GV, Trabattoni D, Morelli M, Borgonovo S, Schneider L, Clerici M. Immune modulation by lactoferrin and curcumin in children with recurrent respiratory infections. Journal of biological regulators and homeostatic agents. Apr-Jun 2009;23(2):119-23.
  13. Cherif H, Bisson DG, Jarzem P, et al. Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cells In Vitro. J Clin Med. 2019 Mar 29;8(4).
  14. You J, Sun J, Ma T, et al. Curcumin induces therapeutic angiogenesis in a diabetic mouse hindlimb ischemia model via modulating the function of endothelial progenitor cells. Stem Cell Res Ther. 2017 Aug 3;8(1):182.
  15. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28.
  16. Taka T, Changtam C, Thaichana P, et al. Curcuminoid derivatives enhance telomerase activity in an in vitro TRAP assay. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5242-6.
  17. Xiao Z, Zhang A, Lin J, et al. Telomerase: a target for therapeutic effects of curcumin and a curcumin derivative in Abeta1-42 insult in vitro. PLoS One. 2014;9(7):e101251.
  18. Hu TY, Liu CL, Chyau CC, et al. Trapping of methylglyoxal by curcumin in cell-free systems and in human umbilical vein endothelial cells. J Agric Food Chem. 2012 Aug 22;60(33):8190-6.
  19. Liu JP, Feng L, Zhu MM, et al. The in vitro protective effects of curcumin and demethoxycurcumin in Curcuma longa extract on advanced glycation end products-induced mesangial cell apoptosis and oxidative stress. Planta Med. 2012 Nov;78(16):1757-60.
  20. Sajithlal GB, Chithra P, Chandrakasan G. Effect of curcumin on the advanced glycation and cross-linking of collagen in diabetic rats. Biochem Pharmacol. 1998 Dec 15;56(12):1607-14.
  21. Lima TFO, Costa MC, Figueiredo ID, et al. Curcumin, Alone or in Combination with Aminoguanidine, Increases Antioxidant Defenses and Glycation Product Detoxification in Streptozotocin-Diabetic Rats: A Therapeutic Strategy to Mitigate Glycoxidative Stress. Oxid Med Cell Longev. 2020;2020:1036360.
  22. Tang Y, Chen A. Curcumin eliminates the effect of advanced glycation end-products (AGEs) on the divergent regulation of gene expression of receptors of AGEs by interrupting leptin signaling. Lab Invest. 2014 May;94(5):503-16.
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  24. Um MY, Hwang KH, Ahn J, et al. Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase. Basic Clin Pharmacol Toxicol. 2013 Sep;113(3):152-7.
  25. Zendedel E, Butler AE, Atkin SL, et al. Impact of curcumin on sirtuins: A review. J Cell Biochem. 2018 Dec;119(12):10291-300.
  26. Bielak-Zmijewska A, Grabowska W, Ciolko A, et al. The Role of Curcumin in the Modulation of Ageing. Int J Mol Sci. 2019 Mar 12;20(5).
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  29. Zia A, Farkhondeh T, Pourbagher-Shahri AM, et al. The role of curcumin in aging and senescence: Molecular mechanisms. Biomed Pharmacother. 2021 Feb;134:111119.
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  31. https://www.lifeextension.com/magazine/2021/ss/curcumin-anti-aging