17/11/2022
Dr. Shade's THE ONE®
A nano-formulated blend of nutraceuticals and botanicals designed to support healthy mitochondrial function, metabolism, and stress resistance.
The unique formulation The One includes Pyrroloquinoline Quinone (PQQ), resveratrol, CoQ10 as ubiquinone, DeltaGold(R) Tocotrienols, and thirteen time-honored adaptogenic botanicals.
Mitochondrial metabolism: An introduction
Every cellular process in our bodies links back to our mitochondria, our precious renewable biological batteries. These tiny, critical organelles have an intimate role within energy production, hormone production, blood clotting, muscle contraction, cell life and cell death.
ATP (adenosine triphosphate)
Up to a thousand mitochondria populate each cell in our body, continuously converting dietary calories into useable energy in the form of ATP (adenosine triphosphate). ATP is so important that the human body recycles it 1000 to 1500 times a day.
Mitochondria also help regulate cellular proliferation, cellular differentiation, cell death (apoptosis), and the removal and recycling of damaged cells and organelles (autophagy and mitophagy). With such an enormous rate of energy production, mitochondria are vulnerable to damage.
Functionality and damage
Through a process known as oxidative phosphorylation, they synthesize ATP but also generate high numbers of reactive oxygen species (ROS).
These ROS serve as signaling molecules that regulate cellular function, but also can cause damage to our DNA. This leads to an extraordinarily high mutation rate in comparison to the nucleus of the cell.
Vulnerability of mitochondria
Mitochondria continuously divide over the course of our lifetime, producing fresh mitochondria through biogenesis. Mitochondrial biogenesis is highly responsive to both energy demand and environmental stimuli.
In addition, as generators of cellular energy, mitochondria serve as first responders to environmental change and stress and are vulnerable to environmental toxins and pollutants.
Supporting mitochondria with innovative nutraceutical combinations may enhance and contribute to their efficient function and biogenesis and induce cytoprotective pathways that can optimize health and preserve youthful, resilient metabolism.
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PQQ enhances mitochondrial biogenesis and offers neuroprotection
Pyrroloquinoline quinone (PQQ) is an antioxidant nutrient with a proven ability to enhance mitochondrial biogenesis and metabolism through multiple pathways and transcription factors.
PQQ stimulates expression of a master regulator molecule called PCG-1a (peroxisome proliferator-activated receptor gamma coactivator 1-alpha).
PCG-1a then activates genes that promote mitochondrial activity and upregulate cellular metabolism, as well as help regulate blood pressure, cholesterol, triglycerides, and energy metabolism.
Mitochondrial reproduction, protection, and repair
Dietary sources of PQQ modulate mitochondrial quantity and function, and everything from lipid metabolism to cardiac ischemia.
In animal studies, deficiency of dietary PQQ leads to stunted growth, reduced fertility and fewer mitochondria. Reintroducing PQQ to the diet increases the number of mitochondria as well as their metabolic efficiency.
Ubiquinone (COQ10) optimizes mitochondrial function
Ubiquinone, the potent lipid antioxidant Coenzyme Q10, supports the ability of mitochondria to produce energy. An astonishing 95% of all cellular energy is dependent upon CoQ10.
CoQ10 facilitates the transfer of electrons (energy) into ATP in the mitochondria. In fact, when CoQ10 has been added to aging mitochondria, their function improved markedly.
COQ10 Encourages improvement of degeneration in vital organs
The age-related decline in female fertility is thought to be due in part to mitochondrial dysfunction, which CoQ10 supplementation has been shown to reverse.
Dysfunction of mitochondria in the brain, related to aging or neurodegenerative conditions, has been improved with CoQ10.
The highest CoQ10 concentrations are found in our most energy-intensive organs: the brain, heart, liver, and kidneys.
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Resveratrol slows aging and clears damaged mitochondria
Mitochondrial dysfunction is a key biomarker of aging. Resveratrol is an antioxidant polyphenol exhibiting a unique range of anti-aging properties. Resveratrol activates the so-called “longevity” enzymes, the sirtuins, mimicking the beneficial effects of calorie restriction.
Like PQQ, resveratrol can stimulate mitochondrial biogenesis and promote mitochondrial respiration, while decreasing ROS and inflammation.
It increases nitric oxide production and benefits the heart, inhibits inflammatory cyclooxygenase, and may help break down beta-amyloid plaque. It increases the activity of the antioxidant enzymes glutathione-peroxidase, S-transferase and S-reductase, superoxide dismutase, and catalase.
Improved mitochondrial function
Resveratrol has been shown to improve mitochondrial function in liver and skeletal muscle cells, as well as induce the formation of new mitochondria in endothelial cells. Treatment with resveratrol helps stimulate mitochondrial biogenesis, an effect that is further enhanced when combined with exercise.
Finally, resveratrol induces both autophagy and mitophagy, helping the body clear damaged cells and thereby reducing inflammation and protecting against oxidative damage.
Tocotrienols increase antioxidant action
Tocotrienols are part of the vitamin E family and are well distributed in the lipid layers of the cell membrane. They offer unique antioxidant, neuroprotective, cholesterol-lowering and anti-inflammatory action. Tocotrienols stimulate our master antioxidant switch, Nrf2.
Delta and gamma tocotrienols sourced from annatto have been shown to lower total cholesterol, LDL, triglycerides and cytokines associated with cardiovascular disease. It also effectively lowers nitric oxide and offers more antioxidant action than alpha tocopherol or a mix of tocopherols and tocotrienols.
Global adaptogens enhance stress resistance
Adaptogenic herbs have a long and celebrated reputation for supporting the body’s response to conditions of high demand. For example, American Ginseng Root (Panax quinquefolius) supports mental acuity and memory and protects neurons from overactivity and toxicity.
Acai berry offers antioxidant and anti-inflammatory action; Himalayan Goji Berry (Lycium barbarum) —the “longevity” berry offers anti-aging, neuroprotective, antioxidant, and supports a balanced immune response.
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References
- References available at quicksilverscientific.com/theonereferences/ TS210027 Rev00
- This information is for the use of licensed healthcare practitioners only and is intended to use as a basis for determining whether to recommend these products to their patients or not. This medical and scientific information is not for use by consumers.
- *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Quicksilver Delivery Systems® improve upon liposomal and emulsification technology with smaller, more stable particles made from the highest-grade ingredients available.
- In addition to exceptional absorption rates, these tiny liposomal and nano-emulsified particles increase diffusion across mucus membranes, enhance lymphatic circulation of nutrients and support cellular delivery.
